SIVA 1 ( SIVA 1 , Apoptosis - Inducing Factor )
نویسندگان
چکیده
Review on SIVA1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
منابع مشابه
Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2.
cis-Diaminedichloroplatinum (II) (cisplatin) is routinely used to treat various types of cancers; however, a significant number develop resistance. One of the underlying factors that contribute to cisplatin resistance is the elevated level of BCL-2 and/or BCL-XL, which promotes cell survival. A potential method of overcoming such resistance is to use a potentiator that is capable of neutralizin...
متن کاملBreast Cancer Cells: Effect of Elevated Levels of BCL-2 Helical Region Enhances Cisplatin-Induced Apoptosis in Expression of Siva-1 Protein or Its Putative Amphipathic
cis-Diaminedichloroplatinum (II) (cisplatin) is routinely used to treat various types of cancers; however, a significant number develop resistance. One of the underlying factors that contribute to cisplatin resistance is the elevated level of BCL-2 and/or BCL-XL, which promotes cell survival. A potential method of overcoming such resistance is to use a potentiator that is capable of neutralizin...
متن کاملThe N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization
Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions. Although many studies have demonstrated that Siva-1 functions in the cytoplasm, a few have found that Siva-1 can relocate to the nucleus. In this study, we found that the first 33 amino acid residues of Siva-1 are required for ...
متن کاملSiva 1 inhibits proliferation, migration and invasion by phosphorylating Stathmin in ovarian cancer cells
Ovarian cancer is one of the most common types of gynecologic malignant tumor, with high incidence and high mortality rates. It is difficult to diagnose ovarian cancer early due to the complex structure and function of the ovaries. Siva 1 is a well-known pro-apoptosis protein that functions in multiple types of cancer cells: There are several studies demonstrating that Siva 1 arrests apoptosis ...
متن کاملEgr-1 Upregulates Siva-1 Expression and Induces Cardiac Fibroblast Apoptosis
The early growth response transcription factor Egr-1 controls cell specific responses to proliferation, differentiation and apoptosis. Expression of Egr-1 and downstream transcription is closely controlled and cell specific upregulation induced by processes such as hypoxia and ischemia has been previously linked to multiple aspects of cardiovascular injury. In this study, we showed constitutive...
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